CAT. NO.: AMA-0777
| Target Information | |
|---|---|
| UniProt ID | Q8TB45 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human, Rat, Monkey |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu113 of human DEPTOR/DEPDC6 protein. |
| Usage | |
|---|---|
| Application | WB, IP, IHC |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50); Immunohistochemistry (1:1000) |
| MW (Target) | 48 kDa |
| Background | |
|---|---|
| DEPTOR/DEPDC6 is a component of both mTORC1 and mTORC2 complexes It interacts with mTOR and inhibits mTORC1 and mTORC2 kinase activities mTOR, along with casein kinase I, phosphorylates DEPTOR/DEPDC6 in the presence of growth signals, which leads to the degradation of DEPTOR/DEPDC6 Research studies have shown that transgenic mice overexpressing DEPTOR/DEPDC6 have more white adipose tissue, and DEPTOR/DEPDC6 expression levels increase in the white adipose tissue of obese humans Furthermore, the expression of DEPTOR/DEPDC6 is induced during mouse adipocyte differentiation Together these findings suggest that DEPTOR/DEPDC6 regulates adipogenesis. | |
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