CAT. NO.: ABA-011
| Product Details | |
|---|---|
| Alternate Name | (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione; Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin; Feruloyl-P-hydroxycinnnamoylmethane; feruloyl-p-coumaroylmethane; 1-(4-Hydroxystyryl)-3-(3-methoxy-4-hydroxystyryl)propanedial; (1E,4Z,6E)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl)-7-(4-hydroxy-phenyl)-hepta-1,4,6-trien-3-one |
| CAS Number | 24939-17-1 |
| Molecular Formula | C20H18O5 |
| Molecular Weight | 338.35 |
| Appearance | A crystalline solid |
| Purity | 95% |
| Solubility | 0.5 mg/mL in ethanol, 10 mg/mL in DMSO and DMF |
| SMILES | COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O |
| PubChem CID | 5469424 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| Demethoxycurcumin is a curcumin derivative with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in KBM-5 cells at 25 μM. It inhibits proliferation of different cell lines such as Jurkat, U937, KBM-5 and H1299 at 25 μM. It suppresses transcriptional coactivator p300 and inhibits the Wnt/beta-catenin pathway. | |
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