DAPT

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CAT. NO.: ABS-014

Product Details
Alternate Name	N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
CAS Number	208255-80-5
Molecular Formula	C₂₃H₂₆F₂N₂O₄
Molecular Weight	432.46
Appearance	White to off-white solid
Purity	≥98% by TLC
Solubility	DMSO (20 mg/mL)
SMILES	CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
PubChem CID	5311272
Handling	Protect from air and moisture.
Storage Conditions	-20°C

Description
Cell permeable. A potent inhibitor of γ-secretase (IC50 = 115 nM for total β-amyloid, IC50 = 200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling.

Description

Cell permeable. A potent inhibitor of γ-secretase (IC50 = 115 nM for total β-amyloid, IC50 = 200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling.

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