Cyclopamine

INQUIRY

CAT. NO.: ABS-012

Product Details
Alternate Name	11-deoxojervine
CAS Number	4449-51-8
Molecular Formula	C₂₇H₄₁NO₂
Molecular Weight	411.62
Appearance	Off-white solid
Purity	≥99%
Solubility	DMSO (4 mg/mL) and EtOH (5 mg/mL)
SMILES	CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
PubChem CID	442972
Handling	Teratogen!
Storage Conditions	-20°C

Description
Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle

Description

Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle

Our customers have direct access to our experts and give timely feedback to any online inquiries. If you are interested in our products, please contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.