CAT. NO.: AMA-0268
| Target Information | |
|---|---|
| UniProt ID | P20248 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val421 of human Cyclin A2 protein. |
| Usage | |
|---|---|
| Application | WB |
| Product Usage Information Dilution | Western Blotting (1:1000) |
| MW (Target) | 55 kDa |
| Background | |
|---|---|
| While overcoming the G1/S checkpoint to commence DNA replication requires cyclin E, and traversing the G2/M checkpoint to initiate mitosis requires cyclin B to be present, cyclin A seems to be required for both S-phase and M-phase. A number of studies have described the ability of overexpressed cyclin A to accelerate the G1 to S transition causing DNA replication, and cyclin A antisense DNA can prevent DNA replication. Cyclin A availability is apparently the rate-limiting step for entry into mitosis, and cyclin A is required for completion of prophase. At late prophase, cyclin A may no longer be necessary as cdc2/cyclinB1 becomes active. | |
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