CAT. NO.: AMA-0434
| Target Information | |
|---|---|
| UniProt ID | Q13619 |
| Product Details | |
|---|---|
| Size | 20 µL/100 µL |
| Reactivity | Human, Monkey |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding residues surrounding Ser12 of human CUL4A. Antibodies are purified by peptide affinity chromatography. |
| Usage | |
|---|---|
| Application | WB, IP |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50) |
| MW (Target) | 80 kDa |
| Background | |
|---|---|
| Cullin-4 (CUL4) is a member of the cullin family of related ubiquitin ligases A pair of mammalian CUL4 proteins - CUL4A and CUL4B - has been identified. The carboxy-terminal domain of CUL4 interacts with Rbx1 and E2 enzyme while the amino-terminal CUL4 domain interacts with BPB domain of UV-damaged DNA binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex This CUL4-DDB1 complex binds a variety of WD40-containing proteins that help to enhance additional substrate recruitment The CUL4 complex has been shown to target substrates involved in DNA repair, cell cycle progression transcription and development. | |
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