CAT. NO.: AMA-0434
| Target Information | |
|---|---|
| UniProt ID | Q13619 |
| Product Details | |
|---|---|
| Size | 20 µL/100 µL |
| Reactivity | Human, Monkey |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding residues surrounding Ser12 of human CUL4A. Antibodies are purified by peptide affinity chromatography. |
| Usage | |
|---|---|
| Application | WB, IP |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50) |
| MW (Target) | 80 kDa |
| Background | |
|---|---|
| Cullin-4 (CUL4) is a member of the cullin family of related ubiquitin ligases A pair of mammalian CUL4 proteins - CUL4A and CUL4B - has been identified. The carboxy-terminal domain of CUL4 interacts with Rbx1 and E2 enzyme while the amino-terminal CUL4 domain interacts with BPB domain of UV-damaged DNA binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex This CUL4-DDB1 complex binds a variety of WD40-containing proteins that help to enhance additional substrate recruitment The CUL4 complex has been shown to target substrates involved in DNA repair, cell cycle progression transcription and development. | |
Our customers have direct access to our experts and give timely feedback to any online inquiries. If you are interested in our products, please contact us.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a contract research organization focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
Copyright © 2024 CD BioSciences. All rights reserved.