Cox-4 Antibody

INQUIRY

CAT. NO.: AMA-0205

Product Details
Reactivity	Human, Mouse, Rat
Host	Rabbit
Source/Isotype	Rabbit IgG
Storage	Store at -20°C.
Purification	Affinity purified

Usage
Application	WB, IHC
Product Usage Information Dilution	Western Blotting (0.5-4 µg/mL); Immunohistochemistry (10-20 µg/mL)

Background
Cytochrome c oxidase (COX) is a 13-subunit complex spanning the inner mitochondrial membrane and responsible for the terminal reduction of dioxygen to water in the electron transport chain. The three core catalytic units COX-1, -2, -3 are trans-membrane proteins encoded by the mitochondrial genome, whereas the remaining 10 subunits are nuclear encoded and expressed in a tissue-specific manner. The expression of nuclear and mitochondrial subunits of the mitochondrial respiratory chain is thoμght to be highly coordinated. Cox-4 is believed to regulate COX activity according to the extramitochondrial ATP/ADP ratio.

Background

Cytochrome c oxidase (COX) is a 13-subunit complex spanning the inner mitochondrial membrane and responsible for the terminal reduction of dioxygen to water in the electron transport chain. The three core catalytic units COX-1, -2, -3 are trans-membrane proteins encoded by the mitochondrial genome, whereas the remaining 10 subunits are nuclear encoded and expressed in a tissue-specific manner. The expression of nuclear and mitochondrial subunits of the mitochondrial respiratory chain is thoμght to be highly coordinated. Cox-4 is believed to regulate COX activity according to the extramitochondrial ATP/ADP ratio.

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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.