CAT. NO.: AMA-0205
| Product Details | |
|---|---|
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. |
| Purification | Affinity purified |
| Usage | |
|---|---|
| Application | WB, IHC |
| Product Usage Information Dilution | Western Blotting (0.5-4 µg/mL); Immunohistochemistry (10-20 µg/mL) |
| Background | |
|---|---|
| Cytochrome c oxidase (COX) is a 13-subunit complex spanning the inner mitochondrial membrane and responsible for the terminal reduction of dioxygen to water in the electron transport chain. The three core catalytic units COX-1, -2, -3 are trans-membrane proteins encoded by the mitochondrial genome, whereas the remaining 10 subunits are nuclear encoded and expressed in a tissue-specific manner. The expression of nuclear and mitochondrial subunits of the mitochondrial respiratory chain is thoμght to be highly coordinated. Cox-4 is believed to regulate COX activity according to the extramitochondrial ATP/ADP ratio. | |
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