CAT. NO.: AMA-0202
| Product Details | |
|---|---|
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. |
| Purification | Affinity purified |
| Usage | |
|---|---|
| Application | WB, IHC |
| Product Usage Information Dilution | Western Blotting (1-4 µg/mL); immunoprecipitation (5 µg/mL); Immunohistochemistry (5 µg/mL) |
| Background | |
|---|---|
| COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drugs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throμghout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. | |
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