Coumarin-SAHA

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CAT. NO.: ABH-005

Product Details
Alternate Name	Coumarin-suberoylanilide hydroxamic acid, N1-Hydroxy-N8-(4-methyl-2-oxo-2H-chromen-7-yl)octanediamide
CAS Number	1260635-77-5
Molecular Formula	C₁₈H₂₂N₂O₅
Molecular Weight	346.38
Appearance	Crystalline solid
Purity	≥98%
Solubility	5 mg/mL in DMSO and DMF
SMILES	CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)CCCCCCC(=O)NO
PubChem CID	53393956
Handling	Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions	-20°C

Description
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor. It is a fluorescent probe that competitively binds HDAC. It is a SAHA derivative where the anilino “cap" group is replaced by 7-amino-4-methylcoumarin. The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively. Fluorescence is quenched by 50% when bound to HDAC8.

Description

Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor. It is a fluorescent probe that competitively binds HDAC. It is a SAHA derivative where the anilino “cap" group is replaced by 7-amino-4-methylcoumarin. The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively. Fluorescence is quenched by 50% when bound to HDAC8.

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