The possibilities for further unraveling the mechanisms of biological aging through the use of new technologies such as next-generation sequencing are rapidly increasing. Comparative genomic analysis has emerged as a powerful tool to study the genetic basis of aging by comparing the genomes of different species or individuals at different age stages. At CD BioSciences, our team of expert biologists and bioinformaticians has a wealth of knowledge in the field of aging research and comparative genomics analysis.
Comparative genomic analysis between representative species of aging
Fig. 1 Representatives of long-lived and short-lived species.
CD BioSciences utilizes state-of-the-art techniques and tools to perform comparative genomic analysis between representative species of aging. We analyze the genomes of different organisms to identify conserved aging-associated genes and functional elements. By comparing the genetic profiles of these species, we can elucidate the evolutionary forces that have shaped the aging process and identify common molecular mechanisms that regulate aging across species.
Comparative genomic analysis of the same species, different age stages
We also offer services to study the genomic changes that occur within the same species at different age stages. This approach allows us to uncover age-related genetic variations and identify genes that are differentially expressed during aging.
Using bioinformatics tools and pipelines, we compare the genomic data obtained from the different samples. By comparing protein sequences or gene locations and relative order across multiple species, we help our clients uncover gene loss, duplication, and horizontal transfer. We elucidate the molecular genetic basis of aging in different species by identifying conserved genes between species (to discover species similarities) or genes that characterize each organism (to discover species differences).
Our services include common analyses, gene family clustering to obtain orthologous genes, phylogenetic analyses, estimation of species divergence times, identification of gene fusions and gene clusters, reconstruction of gene clusters in signaling pathways, gene family contraction and expansion, and genome-wide covariate comparisons. This analysis allows us to identify genes, regulatory regions, and pathways that are associated with aging. We generate comprehensive reports that highlight the key findings and their implications for aging research.
We always combine multiple approaches and tools to gain a comprehensive understanding of the aging genome. We choose the suitable tools depending on the specific experimental setup, data type, and research questions.
| Usage | Analysis Tools |
| Sequence alignment | BLAS, BWA |
| Genome annotation | Ensembl, NCBI |
| Gene expression analysis | DESeq, edgeR |
| Pathway analysis | Reactome, KEGG |
CD BioSciences is equipped with state-of-the-art sequencing technology and bioinformatics tools, which allow us to provide our clients with high-quality results for comparative analysis of aging genomes. If you are interested in our services, please feel free to contact us or make an online inquiry.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a research service provider focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
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