CAT. NO.: ABS-010
| Product Details | |
|---|---|
| Alternate Name | 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile; CT99021 |
| CAS Number | 252917-06-9 |
| Molecular Formula | C22H18Cl2N8 |
| Molecular Weight | 465.34 |
| Appearance | Off-white solid |
| Purity | ≥95% by HPLC |
| Solubility | DMSO ( 100 mM) |
| SMILES | CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N |
| PubChem CID | 9956119 |
| Handling | Protect from air and moisture. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| A potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC50= 6.7 nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a chemically-defined medium in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402. | |
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