Celastrol

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CAT. NO.: ABA-006

Product Details
Alternate Name	(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
CAS Number	34157-83-0
Molecular Formula	C₂₉H₃₈O₄
Molecular Weight	450.61
Appearance	Red solid
Purity	≥98% by TLC
Solubility	DMSO (45 mg/mL) or Ethanol (30 mg/mL)
SMILES	CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
PubChem CID	122724
Handling	Protect from air and moisture.
Storage Conditions	-20°C

Description
Cell-permeable. An Antioxidant, anti-inflammatory and immunosuppressive agent. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC50 = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for prostaglandin E2 and 210 nM for IL-8 and TNF-α). Suppresses nitric oxide (NO) production (IC50 = 230 nM) and LPS-induced NF-κB activation (IC50 = 270 nM). Inhibits chymotrypsin-like activity of 20S proteasome (IC50 = 2.5 µM) and lipid peroxidation induced by ADP and Fe²⁺ in rat liver mitochondria (IC50 = 7 µM).

Description

Cell-permeable. An Antioxidant, anti-inflammatory and immunosuppressive agent. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC50 = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for prostaglandin E2 and 210 nM for IL-8 and TNF-α). Suppresses nitric oxide (NO) production (IC50 = 230 nM) and LPS-induced NF-κB activation (IC50 = 270 nM). Inhibits chymotrypsin-like activity of 20S proteasome (IC50 = 2.5 µM) and lipid peroxidation induced by ADP and Fe²⁺ in rat liver mitochondria (IC50 = 7 µM).

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