CAT. NO.: AMA-0534
| Target Information | |
|---|---|
| UniProt ID | Q16667 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro107 of human CDKN3 protein. |
| Usage | |
|---|---|
| Application | WB, IP |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50) |
| MW (Target) | 23 kDa |
| Background | |
|---|---|
| CDKN3 (Cyclin-Dependent Kinase Inhibitor 3)/KAP (Kinase-Associated Phosphatase) is a dual specificity phosphatase that regulates cell cycle progression through dephosphorylation and inhibition of cyclin-dependent kinases CDKN3 promotes cancer cell proliferation and invasion as well as resistance to cisplatin Overexpression of CDKN3 is associated with tumor progression and poor prognosis in several human cancers. | |
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