CDK2AP1 (E9D7P) Rabbit Antibody

INQUIRY

CAT. NO.: AMA-0407

Target Information
UniProt ID	O14519

Product Details
Size	100 µL
Reactivity	Human, Monkey
Host	Rabbit
Source/Isotype	Rabbit IgG
Storage	Store at -20°C. Do not aliquot the antibody.
Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro12 of human CDK2AP1 protein.

Usage
Application	WB, IP, ChIP
Product Usage Information Dilution	Western Blotting (1:1000); Immunoprecipitation (1:200); Chromatin IP (1:50)
MW (Target)	12 kDa

Background
Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) was first identified as a tumor suppressor in oral cancer and is a member of the nucleosome remodeling and histone deacetylase (NuRD) complex Also known as p12 or DOC-1, CDK2AP1 binds to unphosphorylated CDK2 and DNA polymerase alpha/primase to negatively regulate their activities CDK2AP1 also plays a role in the silencing of Oct-4 during stem cell differentiation Low CDK2AP1 expression in oral cancers is associated with poor prognosis Lower expression has also shown to be resistant to cisplatin treatment In addition to oral cancers, CDK2AP1 plays a role in other tumor types, including colorectal, testicular, and ovarian cancers.

Background

Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) was first identified as a tumor suppressor in oral cancer and is a member of the nucleosome remodeling and histone deacetylase (NuRD) complex Also known as p12 or DOC-1, CDK2AP1 binds to unphosphorylated CDK2 and DNA polymerase alpha/primase to negatively regulate their activities CDK2AP1 also plays a role in the silencing of Oct-4 during stem cell differentiation Low CDK2AP1 expression in oral cancers is associated with poor prognosis Lower expression has also shown to be resistant to cisplatin treatment In addition to oral cancers, CDK2AP1 plays a role in other tumor types, including colorectal, testicular, and ovarian cancers.

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