CAT. NO.: AMA-0297
| Target Information | |
|---|---|
| UniProt ID | Q9H305 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CDIP protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Usage | |
|---|---|
| Application | WB, IP |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50) |
| MW (Target) | 24-26 kDa |
| Background | |
|---|---|
| Cell Death Involved p53-Target (CDIP) is a pro-apoptotic protein induced by genotoxic stress in a p53-dependent manner. Indeed, CDIP is a direct target of p53. Inhibition of CDIP impairs p53-mediated apoptosis. Induction of apoptosis by CDIP requires caspase-8 suggesting involvement in the extrinsic apoptotic pathway. CDIP also promotes increased expression of TNF-α capable of triggering apoptosis. Furthermore, expression of CDIP correlates with increased sensitivity of TNF-α-induced apoptosis. These studies suggest that CDIP may serve as a marker for apoptotic sensitivity. | |
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