CD19 Antibody
Online Inquiry

CD19 Antibody

INQUIRY

CAT. NO.: AMA-0473

Target Information
UniProt ID P15391
Product Details
Size 100 µL
Reactivity Human, Mouse
Storage Store at -20°C. Do not aliquot the antibody.
Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues around the carboxy-terminus of human CD19. Antibodies are purified by protein A and peptide affinity chromatography.
Usage
Application WB, IP, IF, F
Product Usage Information Dilution Western Blotting (1:1000); Immunoprecipitation (1:50); Immunofluorescence (1:50); Flow Cytometry (1:50)
MW (Target) 95 kDa
Background
CD19 is a 95 kDa coreceptor which amplifies the signaling cascade in B cells On the B cell surface, CD19 associates with CD21, CD81, and Leu-13 to exert its function. The cytoplasmic tail of CD19 has nine conserved tyrosine residues playing critical roles in CD19 mediated function by coupling signaling molecules to the receptor After B cell receptor or CD19 ligation, Tyr531 and Tyr500 of CD19 are progressively phosphorylated. This phosphorylation enables the coupling of PI3 kinase and Src family tyrosine kinase to CD19 and activates the PI3K and Src signaling pathways Coligation of B cell receptor and CD19 also promotes Tyr409 phosphorylation in CD19. The phosphorylation at these sites enables its binding to Vav and mediates elevated intracellular calcium response, as well as the JNK pathway.

Our customers have direct access to our experts and give timely feedback to any online inquiries. If you are interested in our products, please contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.