CAT. NO.: AMA-0265
| Target Information | |
|---|---|
| UniProt ID | P20702 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human |
| Host | Mouse |
| Source/Isotype | Mouse IgG1 |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. |
| Usage | |
|---|---|
| Application | IF |
| Product Usage Information Dilution | Immunofluorescence (1:200-1:800) |
| Background | |
|---|---|
| CD11c (integrin αX, ITGAX) is a transmembrane glycoprotein that forms an α/β heterodimer with CD18 (integrin β2), which interacts with a variety of extracellular matrix molecules and cell surface proteins. CD11c is primarily used as a dendritic cell marker. Dendritic cells can be classified into two major types: CD11c+ conventional dendritic cells that specialize in antigen presentation, and CD11c- plasmacytoid dendritic cells that specialize in type I interferon production. CD11c expression has also been observed on activated NK cells, subsets of B cells, monocytes, granulocytes, and some B cell malignancies including hairy cell leukemia. | |
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