CD11c (3.9) Mouse Antibody (FITC Conjugate)

INQUIRY

CAT. NO.: AMA-0383

Target Information
UniProt ID	P20702

Product Details
Size	500 µL
Reactivity	Human
Host	Mouse
Source/Isotype	Mouse IgG1
Storage	Store at -20°C. Do not aliquot the antibody.
Purification	This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Usage
Application	F
Product Usage Information Dilution	Flow Cytometry (1:20)

Background
CD11c (integrin αX, ITGAX) is a transmembrane glycoprotein that forms an α/β heterodimer with CD18 (integrin β2), which interacts with a variety of extracellular matrix molecules and cell surface proteins CD11c is primarily used as a dendritic cell marker. Dendritic cells can be classified into two major types: CD11c+ conventional dendritic cells that specialize in antigen presentation, and CD11c- plasmacytoid dendritic cells that specialize in type I interferon production (2, 3). CD11c expression has also been observed on activated NK cells, subsets of B cells, monocytes, granulocytes, and some B cell malignancies including hairy cell leukemiaThe 3.9 antibody is widely used as a marker for CD11c expression for the cell types mentioned above.

Background

CD11c (integrin αX, ITGAX) is a transmembrane glycoprotein that forms an α/β heterodimer with CD18 (integrin β2), which interacts with a variety of extracellular matrix molecules and cell surface proteins CD11c is primarily used as a dendritic cell marker. Dendritic cells can be classified into two major types: CD11c+ conventional dendritic cells that specialize in antigen presentation, and CD11c- plasmacytoid dendritic cells that specialize in type I interferon production (2, 3). CD11c expression has also been observed on activated NK cells, subsets of B cells, monocytes, granulocytes, and some B cell malignancies including hairy cell leukemiaThe 3.9 antibody is widely used as a marker for CD11c expression for the cell types mentioned above.

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