CAT. NO.: AMA-0429
| Target Information | |
|---|---|
| UniProt ID | P11215 |
| Product Details | |
|---|---|
| Size | 20 µL/100 µL |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human CD11b/ITGAM protein |
| Usage | |
|---|---|
| Application | WB, IHC |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunohistochemistry (1:100-1:400) |
| MW (Target) | 170 kDa |
| Background | |
|---|---|
| Cluster of differentiation molecule 11b (CD11b)/Integrin alpha M (ITGAM) is a transmembrane protein forming heterodimers that are composed of α and β subunits CD11b is expressed by, and commonly used as a marker for, myeloid lineage cells, including neutrophils, monocytes, macrophages, and microglia CD11b is phosphorylated at Ser1126 (cytoplasmic tail) in neutrophils. Research has shown that this phosphorylation event plays a role for leukocytes traveling from the blood stream to tissues Furthermore, genome-wide association studies have linked CD11b to autoimmune diseases, such as systemic lupus erythematous (SLE) | |
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