CD11α (E5S9K) Rabbit Antibody (BSA and Azide Free)

INQUIRY

CAT. NO.: AMA-0350

Target Information
UniProt ID	P20701

Product Details
Size	100 µg
Reactivity	Human
Host	Rabbit
Source/Isotype	Rabbit IgG
Storage	Store at -20°C. Do not aliquot the antibody.
Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val975 of human CD11α protein.

Usage
Application	WB, IHC
MW (Target)	160 kDa

Background
CD11α, also known as integrin alpha-L (ITGAL), is the alpha chain of the lymphocyte function-associated antigen-1 (LFA-1). CD11α combines with the beta chain CD18 (ITGB2) to form LFA-1, an integrin expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1, 2, 3, and 4 F11R/JAM-1 and the secreted form of ubiquitin-like protein ISG15 LFA-1 is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction and transmigration cytotoxic T cell co-stimulation cytotoxic NK cell mediated killing leukocyte clearance and antibody-dependent killing by granulocytes and monocytes LFA-1 is required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. High expression of CD11α has been associated with antigen-specific and tumor-reactive T cells.

Background

CD11α, also known as integrin alpha-L (ITGAL), is the alpha chain of the lymphocyte function-associated antigen-1 (LFA-1). CD11α combines with the beta chain CD18 (ITGB2) to form LFA-1, an integrin expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1, 2, 3, and 4 F11R/JAM-1 and the secreted form of ubiquitin-like protein ISG15 LFA-1 is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction and transmigration cytotoxic T cell co-stimulation cytotoxic NK cell mediated killing leukocyte clearance and antibody-dependent killing by granulocytes and monocytes LFA-1 is required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. High expression of CD11α has been associated with antigen-specific and tumor-reactive T cells.

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