CAT. NO.: AMA-0264
| Target Information | |
|---|---|
| UniProt ID | P38570 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the residues of human CD103/ITGAE protein. |
| Usage | |
|---|---|
| Application | IHC |
| Product Usage Information Dilution | Immunohistochemistry (1:50-1:200) |
| Background | |
|---|---|
| Cluster of differentiation molecule 103 (CD103)/Integrin, alpha E (ITGAE) is a transmembrane protein forming heterodimers that are composed of α and β subunits. CD103/ITGAE is expressed by subsets of CD4+ and CD8+ T cells, dendritic cells, and mast cells in mucosal tissues. The heterodimer composed of CD103/ITGAE and integrin beta 7 interacts with E-cadherin, a cellular adhesion molecule found on epithelial cells. The CD103/ITGAE and integrin beta 7 complex plays a role in thymocyte proliferation, intestinal T cell homing, and the antitumor immune response. Studies have shown that the presence of CD103/ITGAE(+) immune cells can be used as markers for a favorable prognosis in different epithelial cancers. | |
Our customers have direct access to our experts and give timely feedback to any online inquiries. If you are interested in our products, please contact us.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a research service provider focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
Copyright © 2024 CD BioSciences. All rights reserved.