CAT. NO.: ABU-002
| Product Details | |
|---|---|
| Alternate Name | 2-(4'-Carbamoyl-[1,4'-bipiperidin]-1'-yl)-5-(4-methylbenzamido)nicotinic acid |
| CAS Number | 1358488-78-4 |
| Molecular Formula | C25H31N5O4 |
| Molecular Weight | 465.54 |
| Appearance | Crystalline solid |
| Purity | ≥98% by HPLC |
| Solubility | 2 mg/mL DMSO |
| SMILES | O=C(O)C1=C(N2CCC(N3CCCCC3)(C(N)=O)CC2)N=CC(NC(C4=CC=C(C)C=C4)=O)=C1 |
| PubChem CID | 83288403 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| BRD-5529 is a selective, cell-permeable CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction inhibitor (IC50 of 8.6 μM). BRD-5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation and activation of CARD9, and demonstrates cellular activity and selectivity in CARD9-dependent pathways. | |
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