CAT. NO.: TK008
| General Info | |
|---|---|
| Size | 96 Tests / 5x96 Tests |
| Product Overview | This product constitutes a ready-to-use microwell and strip plate ELISA (enzyme-linked immunosorbent assay) Kit designed for the assessment of the Telomerase reverse transcriptase (TERT) ELISA Kit target analytes within biological samples. The concentration gradients of the Kit standards or positive controls render a theoretical Kit detection range in biological research samples containing TERT. The ELISA analytical biochemical technique of the Kit is based on TERT antibody-TERT antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TERT antigen targets in samples. It's important to note that this ELISA Kit is specifically tailored for detecting native, not recombinant TERT. |
| Storage Conditions | Store at 4°C |
| Notes | Occasionally, trace amounts of reagent may remain in the closure of the product vial during shipment and storage of the TERT ELISA kit. It is recommended that any liquid that may be present in the lid of the container be centrifuged to the bottom using a bench-top centrifuge prior to experimentation. |
| Reactivity | Bovine |
| Shipping Conditions | Dry Ice |
| Product Details | |
|---|---|
| Samples | Serum, Plasma, Tissue Homogenates, Other Biological Fluids |
| Detection Range | 0.312-20 ng/mL |
| Detection Wavelength | 450 nm |
| Assay Time | 3-5 h |
| Target Info | |
|---|---|
| Molecular Weight | 124,447 Da |
| NCBI Accession | NP_001039707.1 |
| NCBI GenBank Nucleotide | NM_001046242.1 |
| NCBI GeneID | 518884 |
| NCBI Official Full Name | telomerase reverse transcriptase |
| NCBI Official Symbol | TERT |
| NCBI Protein Information | telomerase reverse transcriptase |
| UniProt Gene Name | TERT |
| UniProt Protein Name | Telomerase reverse transcriptase |
| UniProt Synonym Protein Names | Telomerase catalytic subunit |
| UniProt Primary Accession | Q27ID4 |
| Protein Family | Telomerase reverse transcriptase |
| UniProt Comments | Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis (). |
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