Bax (2D2) Mouse Antibody
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Bax (2D2) Mouse Antibody

INQUIRY

CAT. NO.: AMA-0273

Target Information
UniProt ID Q07812
Product Details
Size 100 µL
Reactivity Human
Host Mouse
Source/Isotype Mouse IgG1
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the N-terminal region of human Bax protein.
Usage
Application WB, IP, IF
Product Usage Information Dilution Western Blotting (1:1000); Immunoprecipitation (1:100); Immunofluorescence (1:6400)
MW (Target) 20 kDa
Background
Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9, and initiation of the caspase activation pathway for apoptosis.

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