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Project Description

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Bax (2D2) Mouse Antibody

INQUIRY

CAT. NO.: AMA-0273

Target Information
UniProt ID	Q07812

Product Details
Size	100 µL
Reactivity	Human
Host	Mouse
Source/Isotype	Mouse IgG1
Storage	Store at -20°C. Do not aliquot the antibody.
Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the N-terminal region of human Bax protein.

Usage
Application	WB, IP, IF
Product Usage Information Dilution	Western Blotting (1:1000); Immunoprecipitation (1:100); Immunofluorescence (1:6400)
MW (Target)	20 kDa

Background
Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9, and initiation of the caspase activation pathway for apoptosis.

Background

Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9, and initiation of the caspase activation pathway for apoptosis.

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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.