AZD8055

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CAT. NO.: ABM-001

Product Details
Alternate Name	5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
CAS Number	1009298-09-2
Molecular Formula	C₂₅H₃₁N₅O₄
Molecular Weight	465.54
Appearance	Yellow solid
Purity	≥98% by HPLC
Solubility	DMSO (100 mg/mL)
SMILES	CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOCC5C
PubChem CID	25262965
Handling	Protect from air and moisture.
Storage Conditions	-20°C

Description
A potent, ATP-competitive inhibitor of mTOR kinase (both mTORC1 and mTORC2) with an IC50 of 0.8 nM. AZD8055 displays excellent selectivity (~ 1,000-fold) against all class I PI3K isoforms and other members of the PI3K-like kinase family. In addition, it shows no significant activity against a panel of 260 kinases at concentrations up to 10 µM. AZD8055 inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins.

Description

A potent, ATP-competitive inhibitor of mTOR kinase (both mTORC1 and mTORC2) with an IC50 of 0.8 nM. AZD8055 displays excellent selectivity (~ 1,000-fold) against all class I PI3K isoforms and other members of the PI3K-like kinase family. In addition, it shows no significant activity against a panel of 260 kinases at concentrations up to 10 µM. AZD8055 inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins.

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