Atherosclerosis is a chronic inflammatory disease of the arteries that leads to the development of plaques within the arterial walls. These plaques, composed of cholesterol, fatty substances, cellular waste products, calcium, and fibrin, can lead to significant structural changes in the intima and the media layer. As a disease strongly associated with aging, atherosclerosis is a major contributor to cardiovascular diseases such as heart attacks and strokes. By constructing atherosclerosis models Researchers can gain insight into the underlying mechanisms that drive these diseases.
Fig. 1 The mechanisms of plaque destabilization and atherothrombosis in the mouse model. (Liu X, et al., 2015)
CD BioSciences has expertise in the development and customization of atherosclerosis models for aging research. Our team of seasoned specialists understands the complex interplay between atherosclerosis and the aging process, enabling us to tailor animal and cell-based models to address clients' specific research needs.
CD BioSciences excels in developing customized in vitro cell-based systems to study the underlying mechanisms of atherosclerosis in aging. Our team can isolate and culture primary cells, such as endothelial cells and smooth muscle cells, to investigate age-related changes in cellular function, signaling pathways, and susceptibility to thrombotic events. Our customized cellular models can be used for high-throughput screening, mechanistic studies, and the evaluation of novel therapeutic interventions targeting aging and atherosclerosis.
CD BioSciences offers a wide range of customized rodent models, including mice and rats, to study the progression of atherosclerosis in aging. Our specialists can modify diet and genetic factors to recapitulate the unique pathophysiology observed in the elderly. Among them, low-density lipoprotein receptor-deficient mice (LDLR−/− mice) and apolipoprotein E-deficient mice (ApoE−/− mice) are the most widely used models. Additionally, we help clients customize transgenic mice expressing mutant forms of apoE, such as apoE3Leiden (E3L), Arg112, and Cys142, which replicate the cardiovascular complications associated with age-related diseases.
Rabbits exhibit a lipoprotein profile and disease progression more closely resembles the human condition. Our team customizes rabbit models of atherosclerosis as invaluable tools for investigating age-related changes in plaque formation, stability, and thrombotic risk. We can tailor these models to assist clients in studying the interplay between aging and vascular dysfunction.
CD BioSciences also provides customized porcine models of atherosclerosis. Given the anatomical and physiological similarities between pigs and humans, our models offer unparalleled translational potential for studying the impact of aging on cardiovascular pathology. Our specialists can engineer porcine models that recapitulate the complex comorbidities associated with aging, such as metabolic syndrome and coronary artery disease.
CD BioSciences is committed to enabling our clients' aging research initiatives through the development of innovative and tailored atherosclerosis models. If you are interested in our services, please feel free to contact us or make an online inquiry.
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CD BioScience is a research service provider focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
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