Atg101 (E1Z4W) Rabbit Antibody

INQUIRY

CAT. NO.: AMA-0627

Target Information
UniProt ID	Q9BSB4

Product Details
Size	100 µL
Reactivity	Human, Mouse, Rat, Monkey
Host	Rabbit
Source/Isotype	Rabbit IgG
Storage	Store at -20°C. Do not aliquot the antibody.
Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val177 of human Atg101 protein.

Usage
Application	WB
Product Usage Information Dilution	Western Blotting (1:1000)
MW (Target)	25 kDa

Background
Atg101 was discovered as a binding protein for Atg13, a component of the ULK1 serine-threonine kinase complex required for autophagy Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents It is generally activated by conditions of nutrient deprivation, but is also associated with a number of physiological processes, including development, differentiation, neurodegeneration, infection, and cancer The molecular machinery of autophagy was largely discovered in yeast and is directed by a number of autophagy-related (Atg) genes. The ULK1 complex includes both Atg13 and FIP200 and is required for starvation-induced autophagy Interaction between Atg101 and Atg13 can be important for the stability and basal phosphorylation of Atg13 and ULK1.

Background

Atg101 was discovered as a binding protein for Atg13, a component of the ULK1 serine-threonine kinase complex required for autophagy Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents It is generally activated by conditions of nutrient deprivation, but is also associated with a number of physiological processes, including development, differentiation, neurodegeneration, infection, and cancer The molecular machinery of autophagy was largely discovered in yeast and is directed by a number of autophagy-related (Atg) genes. The ULK1 complex includes both Atg13 and FIP200 and is required for starvation-induced autophagy Interaction between Atg101 and Atg13 can be important for the stability and basal phosphorylation of Atg13 and ULK1.

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