Assay Kits

Telomeres are repetitive nucleotide sequences located at the ends of chromosomes, and their primary role is to safeguard chromosomes from degradation and the loss of genetic information during cell division. In normal diploid cells, telomeres progressively shorten with each cell cycle. As a result, telomere length gradually decreases over time, and it has been associated with the potential to predict an organism's lifespan. The shortening of telomeres has detrimental effects on various aspects of health and is linked to numerous health conditions, including aging and cancer. Accurate and consistent quantification of telomere length is crucial in several areas of cell biology, including the study of chromosomal stability, DNA repair mechanisms, senescence (cellular aging), apoptosis (programmed cell death), cell dysfunctions, and the development of cancer. Understanding and quantifying telomere length provides valuable insights into these biological processes, contributing to our knowledge of how cells function and age, as well as their involvement in the onset and progression of diseases such as cancer.

Telomeres are repetitive nucleotide sequences located at the ends of chromosomes, and their primary role is to safeguard chromosomes from degradation and the loss of genetic information during cell division. In normal diploid cells, telomeres progressively shorten with each cell cycle. As a result, telomere length gradually decreases over time, and it has been associated with the potential to predict an organism's lifespan. The shortening of telomeres has detrimental effects on various aspects of health and is linked to numerous health conditions, including aging and cancer. Accurate and consistent quantification of telomere length is crucial in several areas of cell biology, including the study of chromosomal stability, DNA repair mechanisms, senescence (cellular aging), apoptosis (programmed cell death), cell dysfunctions, and the development of cancer. Understanding and quantifying telomere length provides valuable insights into these biological processes, contributing to our knowledge of how cells function and age, as well as their involvement in the onset and progression of diseases such as cancer.

Telomeres, consisting of repetitive nucleotide sequences, reside at the ends of chromosomes and serve as protective caps, shielding chromosomes from degradation and genetic information loss. In the natural course of cell division, normal diploid cells undergo telomere shortening with each cycle, leading to a gradual reduction in telomere length. This decline in telomere length has been associated with the potential to predict an organism's lifespan. Accurate and consistent quantification of telomere length is crucial in various facets of cell biology, including the study of chromosomal stability, DNA repair mechanisms, senescence (cellular aging), apoptosis (programmed cell death), cell dysfunctions, and the development of cancer. Mitochondrial DNA (mtDNA), a circular and multicopy genome, is located within the mitochondria, an essential cellular organelle responsible for energy production. The cell's capacity for energy production relies on both the integrity and copy number of mtDNA. There is evidence indicating a positive correlation between telomere length and mitochondrial dysfunction in the context of cellular aging and various age-related disorders, such as cancer, diabetes, and neurodegenerative diseases. A potential mechanistic link between these phenomena has been proposed, involving the PPAR signaling pathway. However, the precise details of this mechanism are still under investigation and require further elucidation.

This product constitutes a ready-to-use microwell and strip plate ELISA (enzyme-linked immunosorbent assay) kit designed for the assessment of the TEL2, telomere maintenance 2, homolog (TELO2) ELISA kit target analytes within biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TELO2. The ELISA analytical biochemical technique of the kit is based on TELO2 antibody-TELO2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TELO2 antigen targets in samples. It's important to note that this ELISA kit is specifically tailored for detecting native, not recombinant TELO2.