CAT. NO.: ABH-001
| Product Details | |
|---|---|
| Alternate Name | cyclo-L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl]Suberoylanilide hydroxamic acid |
| CAS Number | 183506-66-3 |
| Molecular Formula | C34H49N5O6 |
| Molecular Weight | 623.8 |
| Appearance | Off-white solid |
| Purity | ≥95% by HPLC |
| Solubility | DMSO (50 mg/mL) |
| SMILES | CCC(C)C1C(=O)N2CCCCC2C(=O)NC(C(=O)NC(C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC |
| PubChem CID | 6918328 |
| Handling | Protect from air and moisture. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| A potent, cell permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC50 = 50 – 100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible manner. | |
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