Telomeres can be beneficially lengthened with medication. Telomere wear is strongly associated with the onset of age-related disease and death, and there is increasing interest in the specific effects of relevant therapeutic drugs on telomere length. To help researchers advance the development and application of telomere drugs, CD BioSciences provides in vitro studies of drugs to validate their effects on telomere length.
Our Analysis of the Effects of Therapeutic Drugs on Telomere Length
- Assessing the effects of metformin on telomere length
We employ advanced in vitro models to assess the influence of metformin on telomere maintenance. Through meticulous analysis, we elucidate the potential of metformin in preserving telomere integrity and its implications for aging-related conditions.
- Analyzing the effects of rapamycin on telomere length
Through our in vitro assays and analytical methodologies, we delve into the influence of rapamycin on telomere dynamics. Our comprehensive approach enables us to generate valuable data on the potential modulation of telomere length by rapamycin, shedding light on its role in cellular aging and longevity.
- Evaluating the effects of NAD+ precursors on telomere length
We evaluate the effect of NAD+ precursors such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) on telomere length. By studying pathways involved in NAD+ metabolism, DNA repair, and telomere maintenance, we reveal the molecular mechanisms underlying the effects of NAD+ precursors on telomere length.
Workflow for Analysis of the Effects of Therapeutic Drugs on Telomere Length
We focus on providing cost-effective, high-quality experimental research solutions for our customers, specializing in standard and custom in vitro assays that validate the effects of therapeutics on telomere length. We have a wide range of in vitro assays/techniques to assess the specific effects of drugs on telomere length and select specific techniques based on specific research objectives.
- Building cellular models
Our in vitro assay design uses isolated cellular components to monitor biochemical and functional responses to determine the specific mechanisms of action and effects of relevant therapeutic agents on telomere length.
- Cell assays
We have a variety of proprietary cell lines and models for cellular assays including simple cell proliferation and viability assays, oxidative stress and antioxidant assays, apoptosis and senescence assays, and cellular biochemical and functional assays.
- Telomere length measurement
We measure the telomere length telomere parameters such as relative telomere length as well as short telomere distribution, with each sample repeated three times.
- Statistic analysis
We fit univariate regression models to assess crude associations between telomere length and therapeutic drug factors, longitudinally examining between-group differences to systematically assess drug-specific associations.
Our Advantages
- Wide selection of cell-based functional assays to meet your project requirements.
- Explore telomere length-based targets, including other on-demand assays, for final association analysis.
- Flexible and customized services are available to meet your specific needs and support your research goals.
At CD BioSciences, we have been exploring emerging telomere assay technologies and working with our customers to meet their research or industry testing needs. We select core technologies for in vitro studies and telomere measurements, providing solutions for in vitro studies of drug-affected telomere length, as well as professional information and related technology sharing for researchers and pharmaceutical companies to access and test.
We are always developing and advancing new technologies to bring benefits to telomere detection and aging research. If you have a relevant research idea, please contact us and we will be happy to assist you.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
