AIFM2/FSP1 Antibody
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AIFM2/FSP1 Antibody

INQUIRY

CAT. NO.: AMA-0255

Target Information
UniProt ID Q9BRQ8
Product Details
Size 100 µL
Reactivity Human
Storage Store at -20°C. Do not aliquot the antibody.
Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human AIFM2/FSP1 protein. Antibodies are purified by peptide affinity chromatography.
Usage
Application WB
Product Usage Information Dilution Western Blotting (1:1000)
MW (Target) 41 kDa
Background
Apoptosis-inducing factor mitochondria-associated 2 (AIFM2), also known as AIF-homologous mitochondrion-associated inducer of death (AMID) or p53-responsive gene 3 (PRG3), is a homolog of apoptosis-inducing factor (AIF). Research studies show that it inhibits ferroptosis, a form of cell death caused by iron-dependent lipid peroxidation. Therefore, this protein was named as ferroptosis suppressor protein 1 (FSP1). FSP1 is a CoQ oxidoreductase and generates the reduced form of coenzyme Q10, which traps lipid peroxides, leading to the suppression of ferroptosis. Furthermore, inhibition of ferroptosis by FSP1 was shown to be independent of GPX4, another negative regulator of ferroptosis.

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