Aging is becoming a major demographic phenomenon of our time. Of note, aging is the main risk factor for the development of many pathological processes, such as cancer, cardiovascular disease, or neurodegenerative disorders. In recent years, increasing efforts have been made to determine whether the molecular mechanisms involved in aging and lifespan extension are common to mammalian systems. In this regard, mouse models have become an excellent tool in aging research because of their relatively short lifespan (which allows the monitoring of the aging process in a reasonable window frame) and the feasibility of performing genetic manipulations.
Fig. 1 Mice are used to model aging-related diseases in different tissues or organs. (Cai N, et al, 2022)
At CD BioSciences, we have been dedicated to aging research for decades, leveraging our extensive expertise in mouse model development to offer complete solutions for our clients. Our expertise enables clients to delve deep into the complexities of aging, revealing age-related diseases and potential anti-aging therapies.
At CD BioSciences, we offer a wide range of mouse strains, including C57BL/6, BALB/c, and genetically modified models, each with its unique characteristics and suitability for specific research applications.
To study the complex mechanisms of aging, we employ various techniques to induce accelerated aging in our mouse models.
| Aging mouse models | Service details |
| D-galactose-induced senescence model | We administer D-galactose to mouse models to induce the formation of advanced glycation end products (AGEs), which trigger oxidative stress and accelerate the aging process. |
| Total body irradiation (TBI) model | We expose mice to whole-body irradiation, which can induce premature aging by causing DNA damage, cellular senescence, and impaired tissue regeneration. |
| Ozone-induced senescence model | We help clients perform appropriate ozone exposures in mice, which has been shown to accelerate aging by inducing oxidative stress, inflammation, and mitochondrial dysfunction in mice. |
| Genetically engineered models | By manipulating specific genes involved in the aging process, we can assist clients in creating genetically engineered mouse models that exhibit accelerated aging phenotypes, such as Werner syndrome or progeria. |
In addition to whole-body aging models, CD BioSciences specializes in the development of mouse models that recapitulate age-related diseases in specific tissues, organs, or systems.
| Tissue-, organ-, or system-specific mouse models | Service details |
| Models of aging brain or nerve system | We can generate mouse models of age-related neurodegenerative diseases, such as Alzheimer's, Parkinson's, and Huntington's disease. These models exhibit amyloid plaque formation, cognitive decline, and synaptic loss, serving as excellent platforms for testing neuroprotective agents. |
| Models of aging muscle | We customize aging muscle models using genetic modifications. such as knocking down myostatin. These models can be used to study sarcopenia, the age-related loss of muscle mass and function. |
| Models of aging heart | We provide mouse models of age-related cardiovascular diseases, including hypertension, atherosclerosis, and heart failure. Our customized models can be created either by genetic modification (e.g., overexpression of pro-aging genes) or by feeding a high-fat diet. |
| Models of aging liver | Our aging liver models can be utilized to investigate the development of non-alcoholic fatty liver disease and other age-related liver disorders. We help clients customize these models by diets, such as high fructose diets, high cholesterol and bile salt diets, methionine- and choline-deficient diets, as well as choline-deficient, L-amino acid-defined (CDAA) diets. |
| Models of chronic kidney disease (CKD) | Using nephrotoxic chemicals or genetic modifications affecting kidney function, we can construct mouse models that mimic the progression of CKD. |
| Models of osteoarthritis | Our aging mouse models, involving surgical induction of joint instability or genetic modifications affecting cartilage integrity, can be used to study the relationships between osteoarthritis and aging. |
| Models of aging lung | Utilizing cigarette smoke or genetic modifications affecting lung repair mechanisms, we generate mouse models that exhibit age-related lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis. |
The customized aging mouse models developed by CD BioSciences are invaluable tools for the discovery and evaluation of novel anti-aging interventions. These models enable our clients to:
At CD BioSciences, our customized aging mouse models are invaluable tools for understanding the aging process and developing effective anti-aging interventions, ultimately contributing to healthier, longer lives. If you are interested in our services, please feel free to contact us or make an online inquiry.
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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a contract research organization focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
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