Age-Related Respiratory Disease Model Customization Services

Morphological changes in the respiratory system consist of a significantly reduced lung elastic recoil, chest wall rigidity, and respiratory muscle weakness. Aging lungs show significant structural and functional changes. Early investigations of the regulation of airway function and its potential relationship to asthma and chronic obstructive pulmonary disease (COPD) employed large animals, including dogs, cats, and non-human primates. Mouse models provide unique advantages for studying molecular pathogenesis in the context of multiple organ systems and aging.

Fig. 1 Schematic illustration shows a normal young lung and an aged diseased lung. (Aghali A, et al., 2022)

With decades of experience, CD BioSciences is dedicated to offering our expertise in developing customized mouse models for the study of aging lungs and age-related respiratory diseases.

Why Do We Offer Mouse Models for Exploring Aging Lung Changes?

We help clients customize models by selecting appropriate mouse strains that faithfully recapitulate the key features of aging lungs, allowing our clients to understand the mechanisms driving these diseases. Mouse models have the following advantages for studying age-dependent functional changes in the lungs:

• A relatively short time to study the effects of aging.
• Manipulation of gene expression can be used to generate both global and tissue-specific mice.
• Lung function in mice can be measured using invasive and noninvasive methods. Noninvasive measurements are ideal for longitudinal studies to test the effect of aging or any drug treatment.

Customize Mouse Model for Studying Aging Lungs

CD BioSciences offers a range of mouse model customization options based on our client's specific research objectives. For example, we can generate mice with targeted gene knockouts or overexpression, unveiling the roles of various signaling pathways and regulatory molecules in the aging process and airway functions. We offer diverse customized transgenic mouse models including but not limited to:

• Adenylyl cyclase type 5 knockout (AC5KO) mice
• Klotho deficient mice
• Caveolin-1 (Cav-1) knockout mice
• Decorin knockout mice
• Growth hormone (GH) mice
• Growth hormone receptor (GHR) knockout mice
• Senescence marker protein-30 (SMP30) knockout mice
• Senescence-accelerated mouse (SAM): senescence-prone inbred strains (SAMP), senescence-resistant inbred strains (SAMR)

Age-Related Respiratory Disease Model Customization Services

CD BioSciences also offers our clients a wide range of age-related respiratory disease model customization services, allowing them to explore the multifaceted nature of these diseases.

• Mouse models of asthma. We help clients develop mouse models of age-related asthma, which often manifests with different symptoms and responses to treatment.
• Mouse models of COPD. We assist clients in developing customized mouse models of age-related COPD, a debilitating lung disease that becomes increasingly prevalent with advancing age.

With a deep understanding of the underlying mechanisms of lung aging and age-related respiratory diseases, our team at CD BioSciences is uniquely positioned to provide our clients with experimental model customization services to unlock new avenues for groundbreaking research and therapeutic development. If you are interested in our services, please feel free to contact us or make an online inquiry.

References

1. Aghali A, et al. Cellular Senescence in Aging Lungs and Diseases. Cells. 2022, 11 (11): 1781.
2. Mauricio R, et al. Mouse Models to Explore the Aging Lung. 2014, 117-129.