Age-Related Bone Loss Model Customization Services

Age-related bone loss, often leading to osteoporosis, is a significant health concern affecting the elderly population. It is characterized by a deterioration in the microarchitecture of bone tissue and a decrease in bone mass, which impairs bone strength and increases the risk of fracture. Animal models are essential for studying the mechanisms behind age-related bone loss and for testing potential therapeutics.

Fig. 1 Bone changes leading to the senile osteoporotic bone. (Corrado A, et al., 2020)

As a reliable provider of age-related bone loss model customization services, CD BioSciences is proud to offer a comprehensive suite of solutions to support our clients' aging research needs.

Our Age-Related Bone Loss Model Customization Services

Mouse models of age-related bone loss

We provide customized mouse strains with specific genetic modifications, such as the senescence-accelerated mouse (SAM) or the C57BL/6 strain, which exhibit age-related bone loss. Our mouse models serve as versatile tools to help clients investigate the underlying mechanisms of age-related bone loss.

Rat models of age-related bone loss

Rat models have long been a staple in the study of age-related bone loss due to the well-established protocols for inducing and studying this disease. Our team of experts can customize rat models to clients' specific requirements. We work with clients to determine strain selection, age at initiation, and animal modeling approaches (e.g., ovariectomy, parathyroidectomy, hypophysectomy, orchidectomy, glucocorticoid treatment, or combination approaches).

Non-human primate models of age-related bone loss

We also offer non-human primate models for age-related bone loss studies. Our customized models, using macaques or other relevant species, closely mimic human diseases and provide important insights into the complex interplay of hormonal, physiological, and environmental factors that contribute to bone loss in aging.

How Do We Choose the Right Age-Related Bone Loss Models?

To ensure that the clients' study design aligns with scientific advances, our experienced team at CD BioSciences will work closely with clients to assess the research objectives and recommend the optimal experimental models.

• Evaluation of research objectives. Whether our clients are interested in studying the fundamental mechanisms underlying age-related bone loss or evaluating the efficacy of potential therapeutic interventions, our team of scientists helps clients choose the right experimental models to address their scientific questions.
• Assessment of disease progression stages. Different animal models may be better suited to capture specific stages of age-related bone loss, such as the early onset, peak bone loss, or late-stage osteoporosis. Our experts will work with clients to identify the model that aligns with the stage of the disease they aim to investigate.
• Considers of physiological relevance. While rodent models offer valuable insights and efficient experimental workflows, non-human primate models can provide a higher level of translational relevance due to their closer resemblance to human physiology and bone metabolism. We assist our clients in weighing the trade-offs between experimental feasibility and physiological fidelity.

Leveraging our extensive expertise and reliable capabilities, CD BioSciences is positioned to be your trusted partner in customizing age-related bone loss models for aging research. If you are interested in our services, please feel free to contact us or make an online inquiry.

References

1. Corrado A, et al. Molecular Basis of Bone Aging. Int J Mol Sci, 2020, 21 (10): 3679.
2. Black A, et al. A nonhuman primate model of age-related bone loss: a longitudinal study in male and premenopausal female rhesus monkeys. Bone, 2001, 28 (3): 295-302.