CAT. NO.: AF019
| Product Details | |
|---|---|
| Synonym(s) | 5&6DH-DA, CDFDA, Carboxy-DCFDA |
| Empirical Formula (Hill Notation) | C25H14Cl2O9 |
| CAS Number | 127770-45-0 |
| Molecular Weight | 529.28 |
| MDL Number | MFCD08459585 |
| PubChem Substance ID | 57647949 |
| Size | 100 mg |
| Assay | ≥85% (HPCE) |
| Fluorescence | λex 470 nm; λem 529 nm in 0.1 M Tris pH 8.0 (esterase) |
| Storage Temp. | -20°C |
| SMILES string | CC(=O)Oc1cc2Oc3cc(OC(C)=O)c(Cl)cc3C4(OC(=O)c5cc(ccc45)C(O)=O)c2cc1Cl.CC(=O)Oc6cc7Oc8cc(OC(C)=O)c(Cl)cc8C9(OC(=O)c%10ccc(cc9%10)C(O)=O)c7cc6Cl |
| Description | |
|---|---|
| 5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate or CDFDA is a fluorescent oxidant sensing probe. It is an intracellular probe added to the cells as a pro-substrate, which upon hydrolysis by the esterase enzyme produces the fluorescent product called CDF. | |
| Application | |
|---|---|
| 5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate or Carboxy-DCFDA is used as a cell permeate probe to detect intracellular reactive oxygen species (ROS). The anionic fluorescent dye, 5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate is suitable for studying Multi-Drug Resistance (MDR) by target cells. | |
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